Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon
نویسندگان
چکیده
منابع مشابه
Identification of a Novel UT-B Urea Transporter in Human Urothelial Cancer
The urea transporter UT-B is widely expressed and has been studied in erythrocyte, kidney, brain and intestines. Interestingly, UT-B gene has been found more abundant in bladder than any other tissue. Recently, gene analyses demonstrate that SLC14A1 (UT-B) gene mutations are associated with bladder cancer, suggesting that urea transporter UT-B may play an important role in bladder carcinogenesi...
متن کاملAt physiological expression levels the Kidd blood group/urea transporter protein is not a water channel.
The Kidd (JK) blood group locus encodes a urea transporter that is expressed on human red cells and on endothelial cells of the vasa recta in the kidney. Here, we report the identification in human erythroblasts of a novel cDNA, designated HUT11A, which encodes a protein identical to the previously reported erythroid HUT11 urea transporter, except for a Lys(44) --> Glu substitution and a Val-Gl...
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در طی چند دهه ی اخیر، مفهوم «تراژدی» و «قهرمان تراژدی» توجهی روزافرون را تقریباً در تمام حوزه های نقد ادبی به خود معطوف کرده است. برخی نظیر ارسطو، نیچه، و آرتور میلر به بازخوانی آن پرداخته و برخی دیگر نظیر سارتر، استریندبرگ، یوجین اُنیل، برتولت برشت، و آنتونین آرتود به افزودن ابعاد نوینی به این مبحث همت گماشته اند. آنچه قهرمان تراژدی مدرن را از مفهوم کلاسیک آن متمایز می کند نه لغزش تراژیک متداول ...
PURIFICATION AND CHARACTERIZATION OF THE CLONED HUMAN GM-CSF GENE EXPRESSED IN ESCHERICHIA COLI
The human granulocyte-macrophage colony stimulation factor (hGM-CSF) gene was cloned in the pET 23a( +) expression vector under the control of strong bacteriophage T7 transcription and translation signals. The hGM-CSF gene was transferred into E. coli strainBL21 (DE3)pLysS andIPTG was used for induction of GM-CSF gene. Production of the target protein was obtained as revealed by ELISA and ...
متن کاملTransport characteristics of urea transporter-B.
UT-B represents the major urea transporter in erythrocytes, in addition to being expressed in kidney descending vasa recta, brain, spleen, ureter, bladder, and testis. Expression of urea transporter UT-B confers high urea permeability to mammalian erythrocytes. Erythrocyte membranes are also permeable to various urea analogues, suggesting common transport pathways for urea and structurally simi...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2004
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00443.2003